- The placental Extracellular Matrix (ECM) modulates correct cellular reconstruction rather than scar tissue formation. This ECM includes growth factors, fibronectin, laminin, hyaluronic acid, proteoglycans, and other proteins. Anti-inflammatory and anti-fibrotic proteins in placental ECMs reduce inflammation, fibrous tissue growth, and potential scar tissue formation as they downregulate TGF-B, suppress pro-inflammatory cytokines, and inhibit MMPs and fibroblast formation.
FOUNDATION FOR REGENERATION
- Placental ECMs contain Collagens I, III, IV, V, VI, VII, and fibrous proteins that provide a structural scaffold to support migration. Fibronectin, integrins, laminin, and hyaluronan also play a key role in proliferation, differentiation and adherence to the scaffold.