High Efficiency RED 635 nm: The most popular system to study is the effects of LED (632.8 nm) of mitochondria isolated from rat liver. Increased proton electrochemical potential and ATP synthesis was found. Increased RNA and protein synthesis was demonstrated after 10 min irradiation. Pastore et al. found increased activity of cytochrome c oxidase, and an increase in polarographically measured oxygen uptake after 10 min of 632.8 nm ( D. Pastore, M. Greco, V.A. Petragallo and S. Passarella, Increase in H+/e- ratio of the cytochrome c oxidase reaction in mitochondria irradiated LL laser, Biochem Mol Biol Int 34 (1994) 817- 26.
Yellow 592 nm: Increase of the proliferation of vascular cells under 528nm LED. Schindl, Andreas, et al. “Increased Dermal Angiogenesis After Low-Intensity Laser Therapy for a Chronic Radiation Ulcer Determined by a Video Measuring System,” Journal of the American Academy of Dermatology 40.3 (1999): 481-4.
High Efficiency green 540nm: Evaluation of the effect of low-level green LED illumination on the growth of neuroblastoma SH-SY5Y cells cultured with retinoic acid (RA). Neuroblastoma cells were treated with one 30-min dose of green (520-nm) LED illu- mination. It was found that the treatment encouraged multiple neurites’ sprouting and promoted the differentiation process. (E. M. Vinck et al., “Green light emitting diode irradiation enhances fibroblast growth impaired by high glucose level,” Photomed. Laser Surg. 23(2), 167–171 (2005)).
Blue 405nm: Suppression of cancer cell proliferation by a combination of light- emitting diode (LED) irradiation. Kensho Okamoto, Professor, Kagawa University Faculty of Engineering.